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Compounds can either be used as standards and injected individually or a strategy may be employed to pool compounds to allow multiple mixtures to be analyzed per injection.
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An isothiocyanate that potently induces chemopreventative enzymes via Keap1-Nrf2 signaling and ARE-driven gene expression; at 15 μM, inhibits class I and II HDAC activity and suppresses tumor growth selectively in cancerous prostate epithelial cells without affecting normal cells
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Chemical. CAS 938-55-6. Formula C7H9N5. MW 163.18. Synthetic. A puromycin analog that acts as a protein kinase inhibitor. Selectively induces premature mitosis in mammalian cells. Inhibits TNF-alpha upregulation of ICAM-1, lipolysis, and the activation of JNK/SAPK. Inhibits p34cdc2/cyclin B IC50 = 300 µM. Induces apoptosis in S-phase-arrested HeLa cells ~5 mM.
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Thioacetamide (TAA) is an indirect hepatotoxin and causes parenchymal cell necrosis Thioacetamide requires metabolic activation by microsomal CYP2E1 to thioacetamide-S-oxide initially and then to thioacetamide-S-dioxide which is a highly reactive metabolite and its reactive metabolites covalently bind to proteins and lipids thereby causing oxidative stress and centrilobular necrosis Thioacetamide can induce chronic liver fibrosis encephalopathy and other events model[1][2][3][4]
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